HLA alleles modulate EBV viral load in multiple sclerosis
نویسندگان
چکیده
منابع مشابه
HLA-B7-restricted EBV-specific CD8+ T cells are dysregulated in multiple sclerosis.
It was hypothesized that the EBV-specific CD8(+) T cell response may be dysregulated in multiple sclerosis (MS) patients, possibly leading to a suboptimal control of this virus. To examine the CD8(+) T cell response in greater detail, we analyzed the HLA-A2-, HLA-B7-, and HLA-B8-restricted EBV- and CMV-specific CD8(+) T cell responses in a high number of MS patients and control subjects using t...
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The human leukocyte antigen (HLA) complex on chromosome 6p21 has been unambiguously associated with multiple sclerosis (MS). The complex features of the HLA region, especially its high genic content, extreme polymorphism, and extensive linkage disequilibrium, has prevented to resolve the nature of HLA association in MS. We performed a family based association study on the isolated population of...
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Vitamin D response elements (VDREs) have been found in the promoter region of the MS-associated allele HLA-DRB1*15:01, suggesting that with low vitamin D availability VDREs are incapable of inducing *15:01 expression allowing in early life autoreactive T-cells to escape central thymic deletion. The Italian island of Sardinia exhibits a very high frequency of MS and high solar radiation exposure...
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P HYSICIANS AND PATIENTS HAVE ALWAYS HAD A great fascination with the invisible pathogen. Koch’s criteria, set out as early as 1882, have generally been ignored, that is, a microorganism must be (1) present in every case of the disease and (2) isolated from the host with the disease and grown in pure culture, (3) the specific disease must be reproduced when a pure culture of the microbe is inoc...
متن کاملHLA antigens in multiple sclerosis amongst Indians.
The infrequency of multiple sclerosis in India may have genetic implications. We found (a) the HLA-A3 and HLA-B7 haplotypes amongst Indians to be lower than those reported in Caucasians, (b) no excess of HLA-A3 and HLA-B7 amongst our 27 multiple sclerosis patients compared to 330 controls; instead it was the reverse, (c) HLA-B12 as high as 74% in the "clinically definite" cases, against only 9%...
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ژورنال
عنوان ژورنال: Journal of Translational Medicine
سال: 2018
ISSN: 1479-5876
DOI: 10.1186/s12967-018-1450-6